Usable, but not efficiently, with VoiceOver
The app uses a web-like interface for its UI, plus an accessible toolbar. The markup used is in need of some much needed accessibility fixes: No alternative text for images, options to reply, retweet etc., only appear when hovering the mouse over a tweet, and when the timeline refreshes, keyboard focus is lost, making it hard to efficiently read the timeline. Im giving this 3 stars because of the basic accessibility that actually can be improved rather easily. If youre a die-hard user, go ahead and try it. If you just want to tweet along and read your timeline, a Twitter client that is fully based on COCOA widgets is a better bet for you.
MarcoZehe about
Tweetings for Twitter, v2.0.5